Production of various antibodies and single chain Fv molecule against signal-transducing proteins.
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چکیده
منابع مشابه
Production and Evaluation of Specific Single-Chain Antibodies against CTLA-4 for Cancer-Targeted Therapy
Background: Cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) molecules are expressed on T-cells and inhibit their function by inhibiting activation of subsequent T-cell molecular pathways. Blocking of CTLA-4 inhibits the growth of malignant tumor cells. Anti-CTLA-4 monoclonal antibodies activate the immune system against cancer. Due to several advantages of single-chain antibodi...
متن کاملISOLATION BY PHAGE DISPLAY OF SINGLE-CHAIN Fv ANTIBODIES AGAINST Escerichia coli K99 FIMBRIAE
Single-chain antibodies (scFv) are small, recombinant proteins in which variable domains from immunoglobulin heavy and light chains are physically linked with a flexible peptide. They are monovalent and lack the heavy chain constant domins for activation of complement and binding to cellular receptors. However scFvs can possess biological activity by binding to and inhibiting the action of thei...
متن کاملSingle-chain Fv-based anti-HIV proteins: potential and limitations.
The existence of very potent, broadly neutralizing antibodies against human immunodeficiency virus type 1 (HIV-1) offers the potential for prophylaxis against HIV-1 infection by passive immunization or gene therapy. Both routes permit the delivery of modified forms of IgGs. Smaller reagents are favored when considering ease of tissue penetration and the limited capacities of gene therapy vector...
متن کاملProtective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus.
West Nile virus has spread rapidly across the United States, and there is currently no approved human vaccine or therapy to prevent or treat disease. Passive immunization with antibodies against the envelope protein represents a promising means to provide short-term prophylaxis and treatment for West Nile virus infection. In this study, we identified a panel of 11 unique human single-chain vari...
متن کاملproduction and evaluation of specific single-chain antibodies against ctla-4 for cancer-targeted therapy
background: cytotoxic t lymphocyte–associated antigen 4 (ctla-4) molecules are expressed on t-cells and inhibit their function by inhibiting activation of subsequent t-cell molecular pathways. blocking of ctla-4 inhibits the growth of malignant tumor cells. anti-ctla-4 monoclonal antibodies activate the immune system against cancer. due to several advantages of single-chain antibodies (scfvs) ...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1998
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.112.59